|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
UCP2 is deregulated in several human cancers and has been suggested to regulate cancer metabolism.
|
31811866 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The UCP2 inhibitor genipin suppressed xenograft tumor growth and sensitized grafted tumors to gemcitabine treatments.
|
31811866 |
2020 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
UCP2 is deregulated in several human cancers and has been suggested to regulate cancer metabolism.
|
31811866 |
2020 |
|
Malignant neoplasm of gallbladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
UCP2 knockdown suppressed the activation of the NF-κB/β-catenin axis and promoted the increases in mitochondrial ROS in gallbladder cancer cells exposed to gemcitabine treatments.
|
31811866 |
2020 |
|
Gallbladder Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
UCP2 knockdown suppressed the activation of the NF-κB/β-catenin axis and promoted the increases in mitochondrial ROS in gallbladder cancer cells exposed to gemcitabine treatments.
|
31811866 |
2020 |
|
Stage 0 Gallbladder Cancer AJCC v8
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
UCP2 knockdown suppressed the activation of the NF-κB/β-catenin axis and promoted the increases in mitochondrial ROS in gallbladder cancer cells exposed to gemcitabine treatments.
|
31811866 |
2020 |
|
Stage IIA Gallbladder Cancer AJCC v8
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
UCP2 knockdown suppressed the activation of the NF-κB/β-catenin axis and promoted the increases in mitochondrial ROS in gallbladder cancer cells exposed to gemcitabine treatments.
|
31811866 |
2020 |
|
Stage IIB Gallbladder Cancer AJCC v8
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
UCP2 knockdown suppressed the activation of the NF-κB/β-catenin axis and promoted the increases in mitochondrial ROS in gallbladder cancer cells exposed to gemcitabine treatments.
|
31811866 |
2020 |
|
Stage III Gallbladder Cancer AJCC v8
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
UCP2 knockdown suppressed the activation of the NF-κB/β-catenin axis and promoted the increases in mitochondrial ROS in gallbladder cancer cells exposed to gemcitabine treatments.
|
31811866 |
2020 |
|
Stage IV Gallbladder Cancer AJCC v8
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
UCP2 knockdown suppressed the activation of the NF-κB/β-catenin axis and promoted the increases in mitochondrial ROS in gallbladder cancer cells exposed to gemcitabine treatments.
|
31811866 |
2020 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In UCP2 (G-866A) polymorphism, the distribution of GA (46%) and AA (14%) genotypes were significantly higher in T2D patients than the healthy controls.
|
30910560 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
For meta-analysis, a literature search was conducted to identify all studies that investigated associations between UCP2 polymorphisms and DKD in patients with T1DM or type 2 diabetes mellitus.
|
31479096 |
2019 |
|
Hypertensive disease
|
0.590 |
Biomarker
|
group |
BEFREE |
Despite a mild pulmonary hypertension in UCP2-/- mice, hearts from these mice are well preserved against additional pressure overload (severe pulmonary hypertension).
|
30850841 |
2019 |
|
Hypertensive disease
|
0.590 |
AlteredExpression
|
group |
BEFREE |
Conclusions The deletion of DJ -1 leads to oxidative stress-induced hypertension associated with downregulation of NO function, and overexpression of Ucp2 in the kidney increases blood pressure in DJ -1 <sup>-/-</sup> mice.
|
30995881 |
2019 |
|
Fatty Liver
|
0.540 |
AlteredExpression
|
disease |
BEFREE |
Oxidative stress and mitochondrial uncoupling protein 2 expression in hepatic steatosis induced by exposure to xenobiotic DDE and high fat diet in male Wistar rats.
|
31022254 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The present review summarizes the latest findings of UCP2 with respect to obesity, diabetes and cancer.
|
31330574 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Microglial UCP2 Mediates Inflammation and Obesity Induced by High-Fat Feeding.
|
31495690 |
2019 |
|
Steatohepatitis
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
In vitro, CVC inhibited CCL2-induced increases in hepatocyte fatty acid synthase (Fasn) and adipose differentiation-related protein (Adrp), whereas it augmented acyl-coenzyme A oxidase 1 (Acox-1), proliferator-activated receptor gamma co-activator alpha (Pgc1α) and uncoupling protein 2 expression, suggesting mechanisms for attenuated hepatocyte steatosis.
|
30179264 |
2019 |
|
Steatohepatitis
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
Oxidative stress and mitochondrial uncoupling protein 2 expression in hepatic steatosis induced by exposure to xenobiotic DDE and high fat diet in male Wistar rats.
|
31022254 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The present review summarizes the latest findings of UCP2 with respect to obesity, diabetes and cancer.
|
31330574 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polymorphisms of the UCP2 gene have been associated with diabetes and obesity because UCP2 is involved in energy expenditure and insulin secretion.
|
31330574 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, these data suggest that miR-214 regulates diabetes through a ROS/Akt/mTOR signaling pathway by UCP2 in proximal tubular cells.
|
30988734 |
2019 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, these data suggest that miR-214 regulates diabetes through a ROS/Akt/mTOR signaling pathway by UCP2 in proximal tubular cells.
|
30988734 |
2019 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Polymorphisms of the UCP2 gene have been associated with diabetes and obesity because UCP2 is involved in energy expenditure and insulin secretion.
|
31330574 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here we show that expression of mitochondrial uncoupling protein 2 (UCP2) in tumor cells determines the immunostimulatory feature of the tumor microenvironment (TME) and is positively associated with prolonged survival.
|
30664764 |
2019 |